Hydrochloric Acid → HCID 88415079、化合物

HRID 1486261ノート

反応式

HRID 1486261 の反応式
[NH2:1][C:2]([CH3:16])([C:12]([F:15])([F:14])[F:13])[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[ClH:17].[F:13][C:12]([F:15])([F:14])[C:2]([CH3:16])([NH2:1])[CH2:3][NH2:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 90136051rac-tert-Butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate

生成物 1

HCID 88415079HCID 88415079、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 51A in dioxane (188 ml) were admixed with 188 ml of 4 M hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 16 h, then concentrated and stored under argon. This gave 14.4 g (108% of theory) of the target compound, which was not purified any further.

後処理

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound, which was not purified any further

出典と根拠

ORDレコード
ord-97e5fa5daa2b487693a6cc4234586815
出典データセット
uspto-grants-2016_08
特許番号
US09422285B2

反応ノート

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