Hydrazine → 4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2,6-dichlorobenzonitrile
反応式
[C:1](/[N:3]=[C:4](\SC)/[NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([C:13]#[N:14])=[C:8]([Cl:15])[CH:7]=1)#[N:2].[NH2:18][NH2:19]>C(O)C>[NH2:2][C:1]1[NH:19][N:18]=[C:4]([NH:5][C:6]2[CH:11]=[C:10]([Cl:12])[C:9]([C:13]#[N:14])=[C:8]([Cl:15])[CH:7]=2)[N:3]=1参加物
4
実験手順
A solution of (Z)-methyl N′-cyano-N-(3,5-dichloro-4-cyanophenyl)carbamimidothioate (234 mg, 821 μmol, Eq: 1.00) and hydrazine (263 mg, 258 μl, 8.21 mmol, Eq: 10) in ethanol (10 mL) was heated at 65° C. o/n. The reaction mixture was concentrated and chromatographed (23 Supelco, 100% DCM to 5% to 10% MeOH/DCM to give 156 mg (71%) of desired product as an off-white solid.
後処理
- concentrationThe reaction mixture was concentrated
- customchromatographed (23 Supelco, 100% DCM to 5% to 10% MeOH/DCM
出典と根拠
- ORDレコード
- ord-db21468bb2414658aee4eaee8cc833e1
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09428469B2
反応ノート
読み込み中…