Hydrogen Peroxide → 4-Chloro-3,5-bis(trifluoromethyl)benzamide

HRID 1487007ノート

反応式

HRID 1487007 の反応式
[Cl:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].C([O-])([O-])=[O:19].[K+].[K+].OO>CS(C)=O>[Cl:1][C:2]1[C:3]([C:14]([F:15])([F:16])[F:17])=[CH:4][C:5]([C:6]([NH2:7])=[O:19])=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13]

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 226251933,5-Bis(trifluoromethyl)-4-chlorobenzonitrile

生成物 1

HCID 867303704-Chloro-3,5-bis(trifluoromethyl)benzamide収率 93.8%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

4-Chloro-3,5-bis(trifluoromethyl)benzonitrile (1 g, 1.0 eq.) was dissolved in DMSO (10 mL). K2CO3 (0.55 g, 1.1 eq.) and H2O2 (1 mL) were added to the reaction mixture and stirred at room temperature for 2-3 h, then poured into ice water (20 mL). The precipitate formed was collected by filtration and washed with petroleum ether to afford 1.0 g of crude product (90% yield), which was used without further purification in the next step.

後処理

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with petroleum ether

出典と根拠

ORDレコード
ord-00da5095a4d148659b177c1fa89bca13
出典データセット
uspto-grants-2016_08
特許番号
US09428490B2

反応ノート

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