Ammonia → HCID 89815111、化合物

HRID 1487115ノート

反応式

HRID 1487115 の反応式
[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3](OCC)=[O:4].[NH3:18]>>[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3]([NH2:18])=[O:4]

参加物

3

反応物 2

HCID 222AmmoniaHCID 53419335Benzeneacetic acid, α,α-difluoro-3-nitro-, ethyl ester

生成物 1

HCID 89815111HCID 89815111、化合物

反応条件

温度
75 °C

実験手順

A solution of ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate (0.701 g, 2.86 mmol) in Methanolic ammonia (7M, 20.0 ml) was taken in sealed tube. Resulting mixture was heated at 75° C. for 3 hrs. The reaction mixture was concentrated under vacuum and cold water was added to obtain the precipitate. Solid was filtered to obtain 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.515 g).

後処理

  1. customResulting mixture
  2. concentrationThe reaction mixture was concentrated under vacuum and cold water
  3. additionwas added
  4. customto obtain the precipitate
  5. filtrationSolid was filtered

出典と根拠

ORDレコード
ord-8c95057f9b114a829ccbb2c6e29538df
出典データセット
uspto-grants-2016_08
特許番号
US09428499B2

反応ノート

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