Triethylamine → ethyl (2S)-2-methylsulfonyloxypropanoate
反応式
[CH3:1][CH2:2][O:3][C:4]([C@@H:6]([OH:8])[CH3:7])=[O:5].C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C1(C)C=CC=CC=1>[CH3:16][S:17]([O:8][C@@H:6]([CH3:7])[C:4]([O:3][CH2:2][CH3:1])=[O:5])(=[O:19])=[O:18]参加物
5
反応条件
- 温度
- 20 °C
実験手順
To a solution of (L)-ethyl lactate (124 g, 1.05 mol) and triethyl amine (126 g, 1.25 mol) in toluene at 10-15° C. was added methanesulfonyl chloride (124 g, 1.08 mol) dropwise for about 2 hours. The mixture was allowed to warm to about 20° C. and the solid was filtered off. The solution was washed with water and dried, concentrated to afford the product (S)-ethyl 2-(methylsulfonyloxy)propanoate (199 g, yield 96.7%).
後処理
- filtrationthe solid was filtered off
- washThe solution was washed with water
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0a155c1ffb3e4c588be0ebfe0693cf1d
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09428508B2
反応ノート
読み込み中…