Ammonia → 3-Amino-6-iodopyrazine-2-carboxamide

HRID 1487354ノート

反応式

HRID 1487354 の反応式
[NH3:1].[NH2:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][C:6]([I:9])=[CH:7][N:8]=1>O.CO>[NH2:2][C:3]1[C:4]([C:10]([NH2:1])=[O:12])=[N:5][C:6]([I:9])=[CH:7][N:8]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 11087124Methyl 3-amino-6-iodopyrazine-2-carboxylate

生成物 1

HCID 468639523-Amino-6-iodopyrazine-2-carboxamide収率 88%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

30 ml of ammonia in water is added under magnetic stirring to 15 g (53.8 mmol) of a solution of methyl 3-amino-6-iodopyrazine-2-carboxylate in 150 ml of methanol. The reaction medium is stirred at 25° C. for 48 hours. After evaporation of the solvents, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 12.50 g of 3-amino-6-iodopyrazine-2-carboxamide (88%) in the form of a beige solid.

後処理

  1. customAfter evaporation of the solvents
  2. customthe precipitate obtained
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried at 50° C.

出典と根拠

ORDレコード
ord-bf3ff40e2e6f484f89bba172ad18e87e
出典データセット
uspto-grants-2016_08
特許番号
US09428510B2

反応ノート

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