Cyclohexane → HCID 178503531、化合物

HRID 1487360ノート

反応式

HRID 1487360 の反応式
[C:1]([C:3]1[C:4]([S:13][CH3:14])=[N:5][C:6]([OH:12])=[C:7]([CH:11]=1)C(O)=O)#[N:2].C1CCCCC1>C1(OC2C=CC=CC=2)C=CC=CC=1>[OH:12][C:6]1[CH:7]=[CH:11][C:3]([C:1]#[N:2])=[C:4]([S:13][CH3:14])[N:5]=1

参加物

4

反応物 2

HCID 8078CyclohexaneHCID 178503561HCID 178503561、化合物

生成物 1

HCID 178503531HCID 178503531、化合物収率 60.6%

試薬・触媒・溶媒 1

HCID 7583Diphenyl Ether溶媒

実験手順

A solution of 6 g (28.5 mmol) of 5-cyano-2-hydroxy-6-(methylthio)nicotinic acid in 35 ml of diphenyl ether is stirred at 250° C. for 4 hours. After returning to room temperature, 100 ml of cyclohexane is added and the reaction medium is triturated for 30 minutes. The solid formed is filtered, rinsed thoroughly with cyclohexane and then dried under vacuum to yield 2.87 g (60%) of 6-hydroxy-2-(methylthio)nicotinonitrile in the form of a brown powder.

後処理

  1. customAfter returning to room temperature
  2. customthe reaction medium is triturated for 30 minutes
  3. customThe solid formed
  4. filtrationis filtered
  5. washrinsed thoroughly with cyclohexane
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-39754df6f5074d1c8016097b6832d611
出典データセット
uspto-grants-2016_08
特許番号
US09428510B2

反応ノート

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