Hydrochloric Acid → 4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)

HRID 1487814ノート

反応式

HRID 1487814 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:12]1[CH2:13][CH2:14][CH:9]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate2 回

生成物 1

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)収率 57%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Into a 500-mL three neck round-bottom flask, was placed a solution of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.1, 20 g, crude) in ethyl acetate (200 mL). Hydrogen chloride (gas) was introduced to the solution and the resulting mixture was stirred for 30 min at room temperature. The solids were collected by filtration, then washed with ethyl acetate (100 mL) and ether (100 mL) to yield the title compound as a white solid (14 g, 57% over two steps).

後処理

  1. filtrationThe solids were collected by filtration
  2. washwashed with ethyl acetate (100 mL) and ether (100 mL)

出典と根拠

ORDレコード
ord-a799ca846b054023849e06efd76ff7ed
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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