Hydrochloric Acid → Methyl 4-cyclobutyl-5-(1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepin-2-yl)-2-methylbenzoate hydrochloride

HRID 1487955ノート

反応式

HRID 1487955 の反応式
[CH:1]1([C:5]2[CH:10]=[C:9]([CH3:11])[C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:6]=2[C:16]2[NH:32][C:19]3[CH2:20][CH2:21][N:22](C(OC(C)(C)C)=O)[CH2:23][CH2:24][C:18]=3[N:17]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:33]>CCOC(C)=O>[ClH:33].[CH:1]1([C:5]2[C:6]([C:16]3[NH:17][C:18]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20][C:19]=4[N:32]=3)=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[C:9]([CH3:11])[CH:10]=2)[CH2:2][CH2:3][CH2:4]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 90066675t-Butyl 2-(2-cyclobutyl-5-(methoxycarbonyl)-4-methylphenyl)-4,5,7,8-tetrahydroimidazo[4,5-d]azepine-6(1H)-carboxylate2 回

生成物 1

HCID 118250742Methyl 4-cyclobutyl-5-(1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepin-2-yl)-2-methylbenzoate hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Into a 50-mL 3-necked round-bottom flask, was placed a solution of tert-butyl 2-(2-cyclobutyl-5-(methoxycarbonyl)-4-methylphenyl)-4,5,7,8-tetrahydroimidazo[4,5-d]azepine-6(1H)-carboxylate (compound 82.6, 200 mg, 0.46 mmol) in EtOAc (10 mL). Hydrogen chloride (gas) was introduced into the solution by bubbling and the solution was stirred for 30 min at room temperature. The resulting mixture was concentrated under reduced pressure to yield 136 mg (crude) of the title compound as a yellow solid.

後処理

  1. customInto a 50-mL 3-necked round-bottom flask, was placed
  2. customby bubbling
  3. concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3c7bbd3c93b246c4a07eb05d747f30a1
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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