Ammonium Hydroxide → 5-Iodo-4-methyl-1H-pyrazole-3-carboxamide

HRID 1488164ノート

反応式

HRID 1488164 の反応式
[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7](OCC)=[O:8])[C:3]=1[CH3:12].[OH-].[NH4+:14]>CO>[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:14])=[O:8])[C:3]=1[CH3:12]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 90029656Ethyl 3-iodo-4-methyl-1H-pyrazole-5-carboxylate2 回

生成物 1

HCID 900301425-Iodo-4-methyl-1H-pyrazole-3-carboxamide収率 89%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

Into a 100-mL round-bottom flask, was placed a solution of ethyl 5-iodo-4-methyl-1H-pyrazole-3-carboxylate (compound 258.1, 500 mg, 1.79 mmol) in methanol (5 mL). Then ammonium hydroxide (15 mL, 25% aq.) was added and the resulting solution was stirred overnight at 60° C. The mixture was concentrated under reduced pressure to obtain the title compound as a white solid (400 mg, 89%).

後処理

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-03a19117699a41d9bd57505bb7706270
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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