Sodium Methoxide → HCID 90021327、化合物

HRID 1488173ノート

反応式

HRID 1488173 の反応式
[O:1]1[CH2:5][CH2:4][CH:3]([C:6](=[O:9])[CH2:7][CH3:8])[CH2:2]1.[CH3:10][O-:11].[Na+]>C(OCC)=O>[CH3:8][CH:7]([C:6](=[O:9])[CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1)[CH:10]=[O:11]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 21702750HCID 21702750、化合物2 回

生成物 1

HCID 90021327HCID 90021327、化合物収率 66%

試薬・触媒・溶媒 1

HCID 8025Ethyl formate溶媒

実験手順

Into a 100-mL round-bottom flask, was placed 1-(tetrahydrofuran-3-yl)propan-1-one (compound 263.2, 2.5 g, 19.5 mmol), sodium methoxide (1.4 g, 25.9 mmol) and ethyl formate (20 mL). The mixture was stirred overnight at room temperature, then concentrated under reduced pressure. The residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent to obtain the title compound as a yellow solid (2.0 g, 66%).

後処理

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent

出典と根拠

ORDレコード
ord-3ab0b34df5c24500a7d02cc7d3e1aad8
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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