HCID 10490701、化合物 → 4-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole

HRID 1488496ノート

反応式

HRID 1488496 の反応式
[C:1]([N:4]([N:14]1[CH:18]=[N:17][N:16]=[CH:15]1)[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[H][H]>[C].[Pd].CO>[C:1]([N:4]([N:14]1[CH:15]=[N:16][N:17]=[CH:18]1)[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 10490701HCID 10490701、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 106802764-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole収率 98.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A proper amount of 10% palladium-carbon was added to 15 ml of a methanol solution containing 0.38 g of 4-[N-acetyl-N-(4-nitrophenyl)amino]-4H-1,2,4-triazole and the mixture was subjected to catalytic reduction in the presence of hydrogen gas at room temperature for about 40 minutes. After completion of reaction, the catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 0.33 g of 4-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole from the chloroform/methanol (50/1) eluate.

後処理

  1. customAfter completion of reaction
  2. customthe catalyst was removed by filtration
  3. concentrationthe resulting filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-543030bbd0e1499cb92b902e63405881
出典データセット
uspto-grants-1997_10
特許番号
US05674886

反応ノート

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