関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 7-Ethyl-5-nitro-1,3-benzothiazole | HCID 22728036 | — |
| 生成物 | 7-Ethyl-5-aminobenzothiazole | HCID 22728029 | 98.4% |
反応手順
To a solution of SnCl2 (1.5 g, 1.9 mmol) and 5.0 mL of HCl was added 7-ethyl-5-nitrobenzothiazole (0.12 g, 0.57 mmol) in a portion and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aqueous NaOH and extracted with EtOAc and CHCl3. Combined organic layers were dried over Na2SO4 and concentrated in vacuo, yielding an oil (0.10 g, >95%) which was identified as the desired amine (>95% pure) and subjected to a following reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05677321 |
|---|
| 出典データセット | uspto-grants-1997_10 |
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| ORD ID | ord-613ff9b959234f2da14a7c823dd570dc |
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| 出典メモ | uspto-grants-1997_10 |
|---|
