Morpholine → HCID 11062669、化合物

反応式

[C:1](OCC)(=[O:5])[C@H:2]([CH3:4])[OH:3].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[OH:3][C@@H:2]([CH3:4])[C:1]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[O:5]

参加物

反応物 2

HCID 8083Morpholine

HCID 92831(L)-ethyl lactate

生成物 1

HCID 11062669HCID 11062669、化合物収率 68.7%

反応条件

温度: 80 °C

実験手順

A mixture of 75 g of (S)-ethyl lactate and 164 g of morpholine was heated at 80° C. for 64 hours. The reaction solution was concentrated and purified by silica gel chromatography (eluent; hexane:ethyl acetate=4:1 to ethyl acetate) to give 69.4 g of 4-[(S)-2-hydroxypropionyl]morpholine as a pale yellow oil.

後処理

concentrationThe reaction solution was concentrated
custompurified by silica gel chromatography (eluent; hexane:ethyl acetate=4:1 to ethyl acetate)

出典と根拠

ORDレコード: ord-95031e7cfbeb4d218c5cdad1654d3006
出典データセット: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05677464

反応ノート

読み込み中…

参加物