2-(3-Fluorophenyl)ethanamine → [2-(3-Fluoro-phenyl)-ethyl]-{4-[3-(2-piperidin-4-yl-ethyl)-phenyl]-pyrimidin-2-yl}-amine

関与物質

役割	名称	HCID	仕込み量
反応物	2-(3-Fluorophenyl)ethanamine	HCID 533928	—
反応物	4-[2-(4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-ylamino)-ethyl]-2-fluoro-phenol	HCID 67045643	—
生成物	[2-(3-Fluoro-phenyl)-ethyl]-{4-[3-(2-piperidin-4-yl-ethyl)-phenyl]-pyrimidin-2-yl}-amine	HCID 58603492	—

反応手順

Intermediate 92 was coupled with 2-(3-fluoro-phenyl)-ethylamine following procedure F. The resulting product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 406. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.27 (d, 1H), 8.04 (s, 1H), 7.96 (m, 1H), 7.47 (d, 2H), 7.25 (m, 2H), 7.09 (d, 1H), 7.04 (d, 1H), 6.89 (t, 1H), 3.80 (m, 2H), 3.36 (m, 2H), 2.91 (m, 4H), 2.77 (t, 2H), 2.00 (d, 2H), 1.67 (m, 3H), 1.36 (m, 2H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07732444B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-b8dfdda9b16146e69683b1f068aa6cfb
出典メモ	uspto-grants-2010_06