Ammonia → 3-Cyclopentyloxy-4-methoxybenzamide
反応式
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10](Cl)=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:18]>>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10]([NH2:18])=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
Vigorously stirred aqueous ammonia solution (70 mL; 32% w/w) is treated dropwise with warm molten 3-cyclopentyloxy-4-methoxybenzoyl chloride (25.7 g) during a period of 20 minutes, keeping the temperature below 20° C. Stirring is continued at 20° C. for 2 hours, and then the suspension is filtered. The resulting solid is washed with water until free of ammonia, and is then dried under vacuum at 40°-45° C., to give 3-cyclopentyloxy-4-methoxybenzamide (21.78 g), in the form of a buff solid.
後処理
- customthe temperature below 20° C
- filtrationthe suspension is filtered
- washThe resulting solid is washed with water until free of ammonia
- customis then dried under vacuum at 40°-45° C.
出典と根拠
- ORDレコード
- ord-278478a5eeaa46928ead0b67fda1d5e0
- 出典データセット
- uspto-grants-1997_10
- 特許番号
- US05679696
反応ノート
読み込み中…