Thiopheneethanamine → HCID 58603419、化合物

HRID 14902

反応式

HRID 14902 の反応式
C(OC(N1[CH2:11][CH:10]([N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]3[CH:27]=[CH:26][N:25]=[C:24](Cl)[N:23]=3)[CH:17]=2)[CH2:13][CH3:14])C1)=O)(C)(C)C.[S:29]1[CH:33]=[CH:32][CH:31]=[C:30]1[CH2:34][CH2:35][NH2:36]>>[CH2:13]([N:12]([CH2:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([NH:36][CH2:35][CH2:34][C:30]3[S:29][CH:33]=[CH:32][CH:31]=3)[N:23]=2)[CH:19]=[CH:20][CH:21]=1)[CH2:10][C@H:11]1[CH2:17][CH2:16][CH2:15][NH:12][CH2:10]1)[CH3:14]

参加物

3

反応物 2

HCID 116521ThiopheneethanamineHCID 866032993-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-azetidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 58603419HCID 58603419、化合物

実験手順

Intermediate 105 was coupled with 2-thiophen-2-yl-ethylamine following procedure F. The resulting product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 437. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.71 (s, 1H), 8.40 (d, 2H), 7.98 (d, 1H), 7.75 (s, 2H), 7.21 (d, 1H), 6.93 (d, 2H), 4.61 (s, 2H), 4.03 (s, 2H), 3.13 (m, 6H), 2.85 (t, 2H), 2.67 (t, 1H), 2.39 (m, 2H), 1.81 (m, 4H), 1.29 (t, 3H).

出典と根拠

ORDレコード
ord-5d58374880ca4cd58028a606be3a92f8
出典データセット
uspto-grants-2010_06
特許番号
US07732444B2

関連ノート

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