関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-Methoxyquinoline-2-carbonitrile | HCID 230481 | — |
| 試薬 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 試薬 | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| 触媒 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | HCID 178487953 | HCID 178487953 | 87% |
反応手順
General procedure B was applied to 6-methoxyquinoline-2-carbonitrile (184 mg, 1.00mmol). The reaction was stirred at room temperature for 48 hours. Upon completion,volatiles were removed under reduced pressure and the remaining residue was purified by silica gel flash-column chromatography with gradient elution of MeOH/DCM from 0.5 -12.5% over 25 column volumes, affording 6-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)quinoline-2-carbonitrile as a off-white solid (270 mg, 87%);
情報源と証拠
| DOI | 10.1039/c2sc20776a |
|---|
| 出典データセット | Borylation dataset from Roche |
|---|
| ORD ID | ord-5c863801736b4499b0d1a54e4561f8db |
|---|
| 出典メモ | Borylation dataset from Roche |
|---|
