関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzamide | HCID 2331 | — |
| 試薬 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 試薬 | 8-([2,2'-bipyridin]-5-yl)quinolin-2(1H)-one | HCID 164681385 | — |
| 触媒 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 触媒 | Potassium tert-butoxide | HCID 86639980 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide | HCID 2760587 | 9% |
| 生成物 | 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide | HCID 2760588 | 14% |
反応手順
In an argon filled glove box, a 5.0 mL wheaton microreactor was charged with [Ir(cod)(OMe)]2 (1.98 mg, 1.5 mol%), L1 ligand (2.1 mg, 3.5 mol%), B2pin2 (50.8 mg, 1.0 equiv.), KOtBu (1.0 mg, 4.5 mol%), and dry THF (1.0 mL). The reaction mixture was stirred for 2 minutes at room temperature. To this mixture, benzamide (24.2 mg, 0.2 mmol) was added. The microreactor was capped with a teflon pressure cap and placed into pre-heated aluminum block at 80 oC. After 12 h, (judged by GC/MS), we found that the conversion was 23% and meta/para ratio was 1/1.5.
情報源と証拠
| DOI | 10.1002/anie.201809929 |
|---|
| 出典データセット | Borylation dataset from Roche |
|---|
| ORD ID | ord-8a61495c860141f1a8046698b9543528 |
|---|
| 出典メモ | Borylation dataset from Roche |
|---|
