化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1491136作成日：2026年10月27日
1-Chloro-4-(methylthio)benzene → 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491136
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Chloro-4-(methylthio)benzene | HCID 31243 | — |
| 試薬 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 試薬 | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| 触媒 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 溶媒 | P-Xylene | HCID 7809 | — |
| 生成物 | 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 163198006 | 74% |
| 生成物 | HCID 178503174 | HCID 178503174 | 6% |
反応手順
Ligand 3f: A mixture of ortho- and meta-borylated products (114 mg, 80% yield, ortho/meta + para = 12); ortho-borylated product 4e was obtained by further purification by GPC (70 mg, 49% yield), white solid (mp. 80-82 oC);
情報源と証拠
| DOI | 10.1002/anie.201610041 |
|---|
| 出典データセット | Borylation dataset from Roche |
|---|
| ORD ID | ord-903f8118d14f42ecaa64e874e6518ce2 |
|---|
| 出典メモ | Borylation dataset from Roche |
|---|
