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HRID 1491494作成日：2026年10月27日
1-(2-Methoxyphenyl)isoquinoline → 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline
https://huagongshe.com/reaction/1491494
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(2-Methoxyphenyl)isoquinoline | HCID 23159734 | — |
| 試薬 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 試薬 | 4,4,5,5-Tetramethyl[1,3,2]dioxaborolane | HCID 2734768 | — |
| 試薬 | N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine | HCID 67601456 | — |
| 触媒 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline | HCID 101547938 | 88% |
反応手順
Following the general procedure, precipitation from the reaction crude with hexane and trituration afforded 9i (159 mg, 88 %) as a pale solid.
情報源と証拠
| DOI | 10.1002/anie.201104544 |
|---|
| 出典データセット | Borylation dataset from Roche |
|---|
| ORD ID | ord-2dd73b1c305947e1a593c90545f7d2d2 |
|---|
| 出典メモ | Borylation dataset from Roche |
|---|
