4-Bromoanisole → 4-Bromo-2-tert-butyl-1-methoxybenzene

HRID 1491509ノート

反応式

HRID 1491509 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.[C:14](Cl)([CH3:17])([CH3:16])[CH3:15]>O>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:7]=1

参加物

5

反応物 3

HCID 77304-BromoanisoleHCID 10486tert-BUTYL CHLORIDEHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 37338984-Bromo-2-tert-butyl-1-methoxybenzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3.10 g (22.6 mmol) of aluminum chloride are added all at once to a mixture of 63.5 g (339 mmol) of p-bromoanisole and 31.4 g (330 mmol) of tert.butyl chloride. The mixture is stirred at ambient temperature until the evolution of gas ceases (about 15 minutes). The mixture is then heated at 80° C. for 15 minutes and poured into ice. 300 ml of water are added and the mixture is extracted with ether.

後処理

  1. temperatureThe mixture is then heated at 80° C. for 15 minutes
  2. additionpoured into ice
  3. extractionthe mixture is extracted with ether

出典と根拠

ORDレコード
ord-184e8ead30744224b74d5e4fd148544a
出典データセット
uspto-grants-1994_12
特許番号
USRE034805

反応ノート

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