HCID 18953550、化合物 → 4-(1-Pyrrolidinyl)-3-pyridinamine

HRID 1491640ノート

反応式

HRID 1491640 の反応式
[N:1]1([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[N+:12]([O-])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>O1CCOCC1.[C].[Pd]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 2

HCID 18953550HCID 18953550、化合物HCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 189535394-(1-Pyrrolidinyl)-3-pyridinamine収率 90.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

4-pyrrolidine-1-yl-3-nitropyridine (2.10 g, 10.9 mmol) was dissolved in 40 ml of 1,4-dioxane. After the atmosphere was replaced with nitrogen, 0.42 g of 10% palladium-carbon was added thereto. After the atmosphere was replaced with hydrogen, hydrogen addition was conducted with stirring at room temperature for about 15 hours. Palladium-carbon was removed by filtration and the filtered cake was washed with 1,4-dioxane. The filtrate and the washings were combined and then concentrated to obtain 1.61 g of a brown liquid (yield: 90.7%).

後処理

  1. additionwas added
  2. customPalladium-carbon was removed by filtration
  3. washthe filtered cake was washed with 1,4-dioxane
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-2e368c41cc6b46a5b6f740f103b7a660
出典データセット
uspto-grants-1994_12
特許番号
US05371086

反応ノート

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