N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 1491782ノート

反応式

HRID 1491782 の反応式
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

参加物

5

反応物 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

生成物 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazolone収率 89.4%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

This urea (37.5 g) was dissolved in a mixture of 560 mL of methanol and 280 ml of water, and 300 ml of 0.48M hydrochloric acid was added thereto and the resulting mixture was stirred for three days at room temperature. The reaction solution was concentrated under reduced pressure. The crystals thus separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone as a colorless powder.

後処理

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customThe crystals thus separated out
  4. washwere washed with a mixture of water and methanol (5:1)

出典と根拠

ORDレコード
ord-7d9426dd9d8245df809e2f9ba752fa24
出典データセット
uspto-grants-1994_12
特許番号
US05371101

反応ノート

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