6-Chloromethyl-2-cyanopyridine → 6-Phthalimidomethyl-2-pyridinecarbonitrile
反応式
Cl[CH2:2][C:3]1[N:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][CH:4]=1.[C:11]1(=[O:21])[NH:15][C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12.[K]>CN(C)C=O>[C:11]1(=[O:21])[N:15]([CH2:2][C:3]2[N:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][CH:4]=2)[C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12参加物
4
実験手順
A mixture of 6-chloromethyl-2-pyridinecarbonitrile (2.75 g) and potassium phthalimide (3.35 g) in N,N-dimethylformamide (27.5 ml) was stirred at ambient temperature for 4 hours. After the solvent was evaporated in vacuo, water (50 ml) was added to the residue and the resulting precipitate was collected by filtration to give 6-phthalimidomethyl-2-pyridinecarbonitrile (4.60 g).
後処理
- customAfter the solvent was evaporated in vacuo, water (50 ml)
- additionwas added to the residue
- filtrationthe resulting precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-20f8c4dbf93949c9bfd75dc8659db655
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05371097
反応ノート
読み込み中…