Amidinothiourea → 4-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

HRID 1491840ノート

反応式

HRID 1491840 の反応式
Br.C([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13](=O)[CH2:14]Br)[N:8]=1)(=O)C.[NH2:17][C:18](=[N:20][C:21]([NH2:23])=[S:22])[NH2:19]>CO>[NH2:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[N:23]=[C:21]([N:20]=[C:18]([NH2:19])[NH2:17])[S:22][CH:14]=2)[CH:10]=[CH:11][CH:12]=1

参加物

4

反応物 2

HCID 2724563AmidinothioureaHCID 189538712-(Acetylaminomethyl)-6-bromoacetylpyridine hydrobromide

生成物 1

HCID 103997684-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole収率 42.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-(acetylaminomethyl)-6-bromoacetyl-pyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

後処理

  1. temperaturewas refluxed for 10 hours
  2. customThe resulting precipitate was collected
  3. dissolutiondissolved in water (50 ml)
  4. customThe separated product was collected
  5. washwashed with water

出典と根拠

ORDレコード
ord-5cd42c238e234c7aac371864cfa42aca
出典データセット
uspto-grants-1994_12
特許番号
US05371097

反応ノート

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