Hydrochloric Acid → 4-(2-Aminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride
反応式
[ClH:1].C([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:11]=1)(=O)C>C(O)C>[ClH:1].[ClH:1].[NH2:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:11]=1参加物
4
実験手順
Concentrated hydrochloric acid (72.4 ml) was added slowly to a suspension of 4-(2-acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole (6.58 g) in ethanol (280 ml). The mixture was refluxed for 2 hours. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and water afforded 4-(2-aminomethylthiazol-4-yl)-2(diaminomethyleneamino)thiazole dihydrochloride (6.98 g).
後処理
- temperatureThe mixture was refluxed for 2 hours
- filtrationThe resulting precipitate was collected by filtration
- customRecrystallization
- additionfrom a mixture of methanol and water
出典と根拠
- ORDレコード
- ord-32a52234fb7b45e09440b505b5a0c158
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05371097
反応ノート
読み込み中…