4-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide → 4-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole

HRID 1491863ノート

反応式

HRID 1491863 の反応式
Br.[C:2]([NH:5][CH2:6][C:7](=[NH:21])[S:8][CH2:9][C:10]([C:12]1[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=1)=O)(=[O:4])[CH3:3]>C(O)C>[C:2]([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:21]=1)(=[O:4])[CH3:3]

参加物

3

反応物 1

HCID 189537784-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide

生成物 1

HCID 104023264-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole収率 74.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 4-[(2-acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide (11.4 g) in ethanol (100 ml) was refluxed for 2.5 hours. The resulting precipitate was collected by filtration and suspended in water (150 ml). The mixture was alkalized to pH 11 with a saturated aqueous potassium carbonate solution. The resulting precipitate was collected by filtration. Recrystallization from water afforded 4-(2-acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole (6.36 g).

後処理

  1. temperaturewas refluxed for 2.5 hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. filtrationThe resulting precipitate was collected by filtration
  4. customRecrystallization from water

出典と根拠

ORDレコード
ord-c3e1993b409540488714a79014ffdfef
出典データセット
uspto-grants-1994_12
特許番号
US05371097

反応ノート

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