Ethanol → Ethyl 5-benzyloxypentanoate

HRID 1491998ノート

反応式

HRID 1491998 の反応式
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16](O)[CH3:17].S(=O)(=O)(O)O>C(N(CC)CC)C>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 104205755-(Benzyloxy)pentanoic acid

生成物 1

HCID 18953758Ethyl 5-benzyloxypentanoate

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A mixture of 61.1 g of 5-benzyloxypentanoic acid, 566 ml of ethanol and 10 ml of concentrated sulfuric acid is refluxed for 15 h. The mixture is cooled to room temperature, 10 ml of triethylamine are added and evaporated. The residue is diluted with 250 ml of ether and the solution is washed in water and brine dried (MgSO4) and evaporated. The residual oil is distilled to give ethyl 5-benzyloxypentanoate, b.p. 110°-113° C. (0.7 mm/Hg).

後処理

  1. temperatureis refluxed for 15 h
  2. customevaporated
  3. additionThe residue is diluted with 250 ml of ether
  4. washthe solution is washed in water
  5. dry with materialbrine dried (MgSO4)
  6. customevaporated
  7. distillationThe residual oil is distilled

出典と根拠

ORDレコード
ord-6690fe47460a4ce08d4c3bc3fbdb9b2d
出典データセット
uspto-grants-1994_12
特許番号
US05371096

反応ノート

読み込み中…