Potassium Hydroxide → Methyl alpha-{2-[1-(ethoxycarbonyl)-cyclopropylcarbonyloxymethyl]-phenyl}-beta-methoxyacrylate

HRID 1492078ノート

反応式

HRID 1492078 の反応式
C1(C([O-])=O)([C:4]([O:6][CH2:7][CH3:8])=[O:5])CC1.[OH-].[K+].[K].[C:15]1(C([O-])=O)([C:18]([O:20][CH3:21])=[O:19])[CH2:17][CH2:16]1.BrC[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33](=[CH:38][O:39][CH3:40])[C:34]([O:36][CH3:37])=[O:35]>>[CH2:7]([O:6][C:4]([CH:21]([O:20][C:18]([CH:15]1[CH2:16][CH2:17]1)=[O:19])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:27][C:28]=1[C:33](=[CH:38][O:39][CH3:40])[C:34]([O:36][CH3:37])=[O:35])=[O:5])[CH3:8]

参加物

6

反応物 5

HCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 22325078Monomethyl cyclopropane-1,1-dicarboxylateHCID 22722625Monoethyl 1,1-cyclopropanedicarboxylateHCID 53395349Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoate

生成物 1

HCID 67823623Methyl alpha-{2-[1-(ethoxycarbonyl)-cyclopropylcarbonyloxymethyl]-phenyl}-beta-methoxyacrylate収率 66%

実験手順

A method similar to Example 1 was used and 7.9 g (50 mmol) of monoethyl cyclopropane-1,1-dicarboxylate (prepared according to Example 5a) were converted with 2.8 g (50 mmol) of potassium hydroxide into the potassium salt of monomethyl cyclopropane-1,1-dicarboxylate, and said salt was then reacted with 10 g (35 mmol) of methyl alpha-[2-(bromomethyl)-phenyl]-beta-methoxyacrylate. The product was purified by distillation. Yield: 66%; bp.: 220° C. at 0.3 mbar; colorless oil.

後処理

  1. distillationThe product was purified by distillation

出典と根拠

ORDレコード
ord-88032df155db498ba809ae95ad186419
出典データセット
uspto-grants-1994_12
特許番号
US05371268

反応ノート

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