関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Phenol, 4-amino-2,6-dichloro-, hydrochloride (1:1) | HCID 162059 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3',5'-Dichloro-4'-hydroxyacetanilide | HCID 10082180 | 95% |
反応手順
Into a 500 ml round bottom flask (fitted with a magnetic stirrer), water (200 ml) was mixed with 4-amino-2,6-dichlorophenol hydrochloride (20 g) until the solid was completely dissolved. The resulting solution was warmed to 70° C., and to it was added acetic anhydride (11 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of 3', 5'-dichloro-4'-hydroxyacetanilide formed (19.6 g, 95% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05372931 |
|---|
| 出典データセット | uspto-grants-1994_12 |
|---|
| ORD ID | ord-6ea95674393a4909b3414ba0354333ad |
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| 出典メモ | uspto-grants-1994_12 |
|---|
