Bromine → 6-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

HRID 1492134ノート

反応式

HRID 1492134 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:13])([CH3:12])[C:6](=[O:14])[NH:5]2.[Br:15]Br>C(O)(=O)C>[BrH:15].[NH2:1][C:2]1[C:3]([Br:15])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:12])([CH3:13])[C:6](=[O:14])[NH:5]2

参加物

4

反応物 2

HCID 24408BromineHCID 152257137-Amino-3,3-dimethyl-3,4-dihydroquinoxalin-2(1H)-one

生成物 1

HCID 199364056-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of 6-amino-1,2-dihydro-2,2-dimethyl-3-(4H) -quinoxalinone (250 mg, 1.31 mmol ) in glacial acetic acid (4 ml ) is cooled using a water bath. Bromine (210 mg, 1.31 mmol) in acetic acid (0.25 ml) is added dropwise over a 5 minute period. The mixture is stirred at room temperature for 4 hours and the resulting precipitate is collected by vacuum filtration. The title compound is obtained in pure form after drying in vacuo.

後処理

  1. filtrationthe resulting precipitate is collected by vacuum filtration

出典と根拠

ORDレコード
ord-6bc8cc3a3cf447438669320059c53733
出典データセット
uspto-grants-1994_12
特許番号
US05373010

反応ノート

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