Dimethylamine → 1,1-Dimethyl-2-(2-morpholinophenyl)guanidine

HRID 1492234ノート

反応式

HRID 1492234 の反応式
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][NH:20][CH3:21]>C(O)C>[CH3:19][N:20]([CH3:21])[C:4]([NH2:18])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 674DimethylamineHCID 178503978HCID 178503978、化合物

生成物 1

HCID 98854071,1-Dimethyl-2-(2-morpholinophenyl)guanidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (1 g), dimethylamine (1 ml of a 33% solution in ethanol) and ethanol (2 ml) was kept at ambient temperature for 48 days. The mixture was then cooled in an ice bath. The resulting solid was separated by filtration, treated with dilute aqueous sodium hydroxide solution (5 ml) and the resulting mixture extracted with dichloromethane (2×50 ml). The extract was washed with brine, dried and the solvent removed by evaporation to give 1,1-dimethyl-2-(2-morpholinophenyl)guanidine (m.p. 143°-144° C.) which was recrystallised from hexane.

後処理

  1. temperatureThe mixture was then cooled in an ice bath
  2. customThe resulting solid was separated by filtration
  3. additiontreated with dilute aqueous sodium hydroxide solution (5 ml)
  4. extractionthe resulting mixture extracted with dichloromethane (2×50 ml)
  5. washThe extract was washed with brine
  6. customdried
  7. customthe solvent removed by evaporation

出典と根拠

ORDレコード
ord-67e7f2b7501747a6851c57bdc98c64bd
出典データセット
uspto-grants-1994_12
特許番号
US05373008

反応ノート

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