Methylamine → HCID 178484924、化合物

反応式

I.CS[C:4](=[N:19][CH2:20]CCC)[NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[CH3:24][NH2:25]>>[CH3:24][NH:25][C:4]([NH:19][CH3:20])=[N:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

参加物

反応物 2

HCID 6329Methylamine

HCID 189522972-Methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide

生成物 1

HCID 178484924HCID 178484924、化合物

実験手順

A mixture of 2-methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide (3.4 g) and a 33% ethanolic solution of methylamine (10 ml) were stored at ambient temperature in a sealed container for 8 months to yield 1,3-dimethyl-2-(5-chloro-2-morpholinophenyl)guanidine (m.p. 145°-146° C.) which was recrystallised from hexane. In this reaction the butylamino and the methylthio group of the starting material are replaced by a methylamino group.

出典と根拠

ORDレコード: ord-1ce9eaf7e87c4b59b54ff885d0b84d91
出典データセット: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05373008

反応ノート

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