Potassium Iodide → HCID 18950367、化合物

HRID 1492379ノート

反応式

HRID 1492379 の反応式
Br[CH2:2][C:3]#[C:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[I-].[K+].[OH:14][N:15]1[C:19](=[O:20])[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:17]2[C:16]1=[O:25].C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[C:6]1([CH2:5][C:4]#[C:3][CH2:2][O:14][N:15]2[C:16](=[O:25])[C:17]3=[CH:24][CH:23]=[CH:22][CH:21]=[C:18]3[C:19]2=[O:20])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 10665N-HydroxyphthalimideHCID 11430Potassium CarbonateHCID 18950366HCID 18950366、化合物

生成物 1

HCID 18950367HCID 18950367、化合物

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

51.3 g (0.23 mol) of the 1-bromo-4-phenyl-2-butyne obtained above were added dropwise in the course of 30 minutes to a mixture consisting of 230 ml of N-methylpyrrolid-2-one, 3 g of potassium iodide, 37 g (0.23 mol) of N-hydroxyphthalimide and 20.6 g (0.15 mol) of potassium carbonate. Stirring was carried out for a further 5 hours at 60° C. and then overnight at room temperature, the mixture was poured into 800 ml of ice water and the precipitated crystals were filtered off under suction and washed thoroughly with water and isopropanol.

後処理

  1. additionabove were added dropwise in the course of 30 minutes to a mixture
  2. filtrationthe precipitated crystals were filtered off under suction
  3. washwashed thoroughly with water and isopropanol

出典と根拠

ORDレコード
ord-32699b79342243748f3232b32fd45deb
出典データセット
uspto-grants-1994_12
特許番号
US05374609

反応ノート

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