Water → HCID 18950689、化合物

HRID 1492553ノート

反応式

HRID 1492553 の反応式
[NH2:1][CH:2]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1.C(N(CC)CC)C.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1.O>ClCCl>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([NH:1][CH:2]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:3][CH2:4][C:5]2[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=2)(=[O:37])=[O:36])=[CH:31][CH:30]=1

参加物

6

反応物 4

HCID 962WaterHCID 73984-Chlorobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 18950694HCID 18950694、化合物

生成物 1

HCID 18950689HCID 18950689、化合物収率 59%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 10 ml of the solution of 0.35 g of methyl 4-[3-amino-3-(3-pyridyl)propyl]benzoate in dichloromethane were added 0.22 ml of triethylamine and 0.33 g of p-chlorobenzene sulfonylchloride, and stirred at room temperature overnight. After completion of the reaction, the reaction mixture was poured into water, which was then extracted with dichloromethane, washed in saturated aqueous sodium chloride, and dried over magnesium sulfate. The residue was subjected to chromatography on a silica gel column, to obtain 0.34 g of methyl 4-[3-(4-chlorobenzenesulfonamido)-3-(3-pyridyl)propyl]benzoate. The spectrometric data supports the structure of [36] as follows.

後処理

  1. customAfter completion of the reaction
  2. extractionwas then extracted with dichloromethane
  3. washwashed in saturated aqueous sodium chloride
  4. dry with materialdried over magnesium sulfate

出典と根拠

ORDレコード
ord-cfab2476c3834deba4b5587b8f4a7924
出典データセット
uspto-grants-1994_12
特許番号
US05374641

反応ノート

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