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Allyl bromide → 4-Allyloxy-3-allylbenzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 3-allyl-4-hydroxybenzoate | HCID 939882 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-Allyloxy-3-allylbenzoic acid methyl ester | HCID 11241748 | 87% |
反応手順
A solution of 3.04 g (15.8 mmol) of methyl 4-hydroxy-3-propenylbenzoate (Example 7, Step B) was refluxed with anhydrous potassium carbonate (4.37 g, 2 equiv) and allyl bromide (3.5 mL. 2.5 equiv) in acetone overnight. The mixture was filtered through celite and the filter cake was washed with more acetone and dichloromethane. After removing the solvents, the resulting oil was distilled under high vacuum to give 3.2 g (87%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05374638 |
| 出典データセット | uspto-grants-1994_12 |
| ORD ID | ord-a9313012b2f845a988c69a43cfbde043 |
| 出典メモ | uspto-grants-1994_12 |