Hydrochloric Acid → HCID 178493552、化合物

HRID 1493091ノート

反応式

HRID 1493091 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH2:12])[N:4]=1.[ClH:13].[N:14]#[C:15][NH2:16]>C(O)C>[ClH:13].[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH:12][C:15]([NH2:16])=[NH:14])[N:4]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 9864CyanamideHCID 144790742-Hydrazinyl-4,6-dimethoxypyrimidine

生成物 1

HCID 178493552HCID 178493552、化合物収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 17.0 g (0.1 mol) of 4,6-dimethoxy-2-hydrazino-pyrimidine, 8.3 ml of concentrated hydrochloric acid, 4.2 g (0.1 mol) of cyanamide and 100 ml of ethanol is boiled to reflux for 18 hours. The mixture is then evaporated, the residue is crystallized using diethyl ether, and the crystalline product is isolated by filtering off with suction. 22.9 g (92% of theory) of (4,6-dimethoxy-pyrimidin-2-yl-amino)-guanidine hydrochloride of melting point 214° C. are obtained.

後処理

  1. temperatureto reflux for 18 hours
  2. customThe mixture is then evaporated
  3. customthe residue is crystallized
  4. customthe crystalline product is isolated
  5. filtrationby filtering off with suction

出典と根拠

ORDレコード
ord-7001074c92aa4970aee78a943d85a89a
出典データセット
uspto-grants-1991_06
特許番号
US05021082

反応ノート

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