Thiopheneethanamine → (4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-thiophen-2-yl-ethyl)-amine

HRID 14931

反応式

HRID 14931 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]3[CH:29]=[CH:28][N:27]=[C:26](Cl)[N:25]=3)[CH:19]=2)[CH2:15][CH3:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[S:31]1[CH:35]=[CH:34][CH:33]=[C:32]1[CH2:36][CH2:37][NH2:38]>>[CH2:15]([N:14]([CH2:17][C:18]1[CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:38][CH2:37][CH2:36][C:32]3[S:31][CH:35]=[CH:34][CH:33]=3)[N:25]=2)[CH:21]=[CH:22][CH:23]=1)[CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH3:16]

参加物

3

反応物 2

HCID 116521ThiopheneethanamineHCID 866032904-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 58603588(4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-thiophen-2-yl-ethyl)-amine

実験手順

Intermediate 84 was coupled with 2-thiophen-2-yl-ethylamine following procedure F. The product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 422.

出典と根拠

ORDレコード
ord-0da0f5fd3bec4c559704afb8fa2e8a8c
出典データセット
uspto-grants-2010_06
特許番号
US07732444B2

関連ノート

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