1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride → 1-(5,6-Dichloroindan-1-carbonyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride

HRID 1493150ノート

反応式

HRID 1493150 の反応式
[ClH:1].Cl.Cl.[CH3:4][N:5]1[CH2:10][CH2:9][NH:8][CH:7]([CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:6]1.[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][C:26]=1[Cl:27])[CH:23]([C:28](Cl)=[O:29])[CH2:22][CH2:21]2>C(N(CC)CC)C>[ClH:17].[ClH:1].[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][C:26]=1[Cl:27])[CH:23]([C:28]([N:8]1[CH2:9][CH2:10][N:5]([CH3:4])[CH2:6][CH:7]1[CH2:11][N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:29])[CH2:22][CH2:21]2

参加物

4

反応物 2

HCID 189151091-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochlorideHCID 189151665,6-Dichloroindan-1-carbonyl chloride

生成物 1

HCID 189150431-(5,6-Dichloroindan-1-carbonyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride収率 109.2%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

The procedure described in Example 24 was repeated, but using 1.67 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 3.6 ml of triethylamine and 1.5 g of 5,6-dichloroindan-1-carbonyl chloride, to afford 1.54 g of the title compound, melting at 245 °-250° C.

出典と根拠

ORDレコード
ord-a93adaff8d224fd7a775b2ea89524939
出典データセット
uspto-grants-1991_06
特許番号
US05021413

反応ノート

読み込み中…