N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDE → HCID 14801070、化合物

HRID 1493199ノート

反応式

HRID 1493199 の反応式
Cl[CH2:2][N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Cl)=[O:5].[Cl:13][C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][C:29]=1[Cl:30])[CH2:17][NH:18][C:19]([NH:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[S:20]>C1C=CC=CC=1>[F:26][C:23]([F:24])([F:25])[CH2:22][N:21]=[C:19]1[N:18]([CH2:17][C:16]2[CH:27]=[CH:28][C:29]([Cl:30])=[C:14]([Cl:13])[CH:15]=2)[C:4](=[O:5])[N:3]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:2][S:20]1

参加物

4

反応物 2

HCID 11241146N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDEHCID 14801046HCID 14801046、化合物

生成物 1

HCID 14801070HCID 14801070、化合物収率 40.2%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

1.00 g of N-chloromethyl-N-phenylcarbamoyl chloride and 1.55 g of 1-(3,4-dichlorobenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 m1 of benzene, and the solution was heated under reflux. After the reaction, benzene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography silica gel; eluent: hexane/ethyl acetate (10/1)] to give 0.88 g of the captioned compound.

後処理

  1. temperaturethe solution was heated
  2. temperatureunder reflux
  3. customwas evaporated under reduced pressure
  4. customThe resulting oily product was purified by column chromatography silica gel

出典と根拠

ORDレコード
ord-822bce15d72446bc9e3832e14ff70787
出典データセット
uspto-grants-1991_06
特許番号
US05021412

反応ノート

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