Ethanamine, 2,2,2-trifluoro- → HCID 14801043、化合物
反応式
[C:1]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([N:11]=[C:12]=[S:13])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]([F:21])([F:20])[CH2:18][NH2:19]>>[C:1]([C:5]1[CH:15]=[CH:14][C:8]([CH2:9][NH:11][C:12]([NH:19][CH2:18][C:17]([F:21])([F:20])[F:16])=[S:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
10.82 g of 4-t-butylbenzoyl isothiocyanate obtawined in (1) and 7.54 g of 2,2,2-trifluoroethylamine were dissolved in 20 ml of ethyl acetawte. The solution was left to stand at room temperature for 24 houirs. Ethyl acetate was evaporated under reduced prerssure. The resultilng oily product was purified by column chromatography silica gel; developing solvent hexane/ethyl acetate (4:1)) to give 15.80 g of the desired 1-(4-t-butylbenzyl)-3-(2,2,2-trifluoroethyl)thiourea.
後処理
- dissolutionwere dissolved in 20 ml of ethyl acetawte
- waitThe solution was left
- customto stand at room temperature for 24 houirs
- customEthyl acetate was evaporated under reduced prerssure