Acetyl chloride → Acetamide, N-(2,6-dichlorophenyl)-

HRID 1493496ノート

反応式

HRID 1493496 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[C:10](Cl)(=[O:12])[CH3:11]>C(O)(=O)C>[CH3:11][C:10]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[O:12]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 118462,6-Dichloroaniline

生成物 1

HCID 28698Acetamide, N-(2,6-dichlorophenyl)-

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
90 °C

実験手順

To a mechanically stirred solution of 2,6-dichloroaniline (76 g, 0.047 mol) in 60 mL of glacial acetic acid is added dropwise acetyl chloride (36 mL, 0.5 mol). After the addition is complete, the reaction mixture is heated at 90° C. for 20 minutes. The solution is poured into ice water (500 mL), forming a white precipitate. The solids are filtered, washed with water and dried to give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. from glacial acetic acid).

後処理

  1. additionAfter the addition
  2. customforming a white precipitate
  3. filtrationThe solids are filtered
  4. washwashed with water
  5. customdried
  6. customto give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. from glacial acetic acid)

出典と根拠

ORDレコード
ord-98ed9fce6a324ceab8053d2b51e9f9a4
出典データセット
uspto-grants-1991_06
特許番号
US05021576

反応ノート

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