Acetamide, N-(2-methyl-4-nitrophenyl)- → 2-Methyl-6-nitroaniline
反応式
C([NH:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:14])(=O)C.C(NC1C=CC([N+]([O-])=O)=CC=1C)(=O)C>>[NH2:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:14]参加物
3
実験手順
The wet mixture of 2-acetylamino-3-nitrotoluene (4) and 2-acetylamino-5-nitrotoluene as obtained in Preparation Example 1 was placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid was added thereto. Immediately on heating and boiling, the mixture was hydrolyzed. The boiling was continued until 36 l of a distillate was collected. On cooling the distillate, there was obtained 2-amino-3-nitrotoluene (5) as an orange needle-like crystal having a melting point of 92.8° to 93.2° C. and a 46% yield.
後処理
- customas obtained in Preparation Example 1
- distillationwas placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid
- additionwas added
- temperatureImmediately on heating
- customwas collected
- temperatureOn cooling the distillate, there
出典と根拠
- ORDレコード
- ord-7b49919bcd514aa6b4eb47578b0c1942
- 出典データセット
- uspto-grants-1991_06
- 特許番号
- US05021593
反応ノート
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