Ethanol → N'-[1-(Pyridin-2-yl)ethylidene]benzohydrazide

HRID 1493686ノート

反応式

HRID 1493686 の反応式
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)(=O)[CH3:12].C(O)C>O1CCOCC1>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:11](=[N:10][NH:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:12]

参加物

5

反応物 3

HCID 702EthanolHCID 11955BenzoylhydrazineHCID 142862-Acetylpyridine

生成物 1

HCID 1072163N'-[1-(Pyridin-2-yl)ethylidene]benzohydrazide収率 64%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 6.81 gm (0.05 mole) of benzhydrazide, 6.06 gm (0.05 mole) of 2-acetylpyridine and 100 ml of ethanol is stirred at reflux 2 hr. Then sufficient dioxane is added to the boiling mixture to furnish a solution. The hot solution is filtered. The filtrate is diluted to the cloud point with water, cooled to room temperature, and then chilled in the refrigerator. The product is collected and dried to yield 7.61 gm (64%) of the title compound having a melting point of 151.6° C.

後処理

  1. temperatureat reflux 2 hr
  2. customto furnish a solution
  3. filtrationThe hot solution is filtered
  4. additionThe filtrate is diluted to the cloud point with water
  5. temperaturechilled in the refrigerator
  6. customThe product is collected
  7. customdried

出典と根拠

ORDレコード
ord-74c2e0002ae14275a41098f9debcca1d
出典データセット
uspto-grants-1991_06
特許番号
US05023334

反応ノート

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