Hydrochloric Acid → 15-Hydroxypentadecanoic acid

HRID 1493722

反応式

HRID 1493722 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][C:5](=O)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].[OH-].[K+].C(O)COCCO.Cl>O>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8117Diethylene GlycolHCID 14797Potassium HydroxideHCID 988195515-Hydroxy-12-ketopentadecanoic acid

生成物 1

HCID 7836015-Hydroxypentadecanoic acid収率 85%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.00 g (3.68 millimole) of 15-hydroxy-12-ketopentadecanoic acid, 0.73 g (11.0 millimole) of 85 wt.% potassium hydroxide, 0.50 g (8.5 millimole) of 85 % hydrated hydrazine and 5 ml of diethylene glycol were charged into a frask and heated under reflux over 1.5 hours. Subsequently, while evaporating the produced light boiling components such as water to the outside of the system, the internal temperature was elevated to 195 to 205° C., and the heating under reflux was continued at the same temperature range over 2 hours. After completion of the reaction, the solution was cooled, diluted by addition of 5 ml of water and added with 3 ml of 6N-HCl, followed by collection of the precipitated pail brown solid by filtration. The solid was recrystallized from benzene to obtain 0.81 g (3.14 millimole, Yield: 85 %) of a white crystl.

後処理

  1. temperatureheated
  2. temperatureunder reflux over 1.5 hours
  3. customSubsequently, while evaporating the produced light
  4. customwas elevated to 195 to 205° C.
  5. temperaturethe heating under reflux
  6. customAfter completion of the reaction
  7. temperaturethe solution was cooled
  8. filtrationfollowed by collection of the precipitated pail brown solid by filtration
  9. customThe solid was recrystallized from benzene
  10. customto obtain 0.81 g (3.14 millimole, Yield: 85 %) of a white crystl

出典と根拠

ORDレコード
ord-bc798a77a48a49ffaf13ef4043394149
出典データセット
uspto-grants-1991_06
特許番号
US05023351

関連ノート

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