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Butyl bromide → N-butyl-N-acetyl-2,4-difluoroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Butyl bromide | HCID 8002 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Acetamide, N-(2,4-difluorophenyl)- | HCID 96093 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-butyl-N-acetyl-2,4-difluoroaniline | HCID 19827549 | 68.7% |
反応手順
0.9 g of triethylbenzylammonium chloride, 6.9 g of butyl bromide and a solution of 5.7 g of KOH in 6 ml of water are added to a stirred solution of 3.4 g of N-acetyl-2,4-difluoroaniline (Example 2) in 60 ml of toluene. The emulsion produced is warmed at 97° (reflux). After 1 h, the emulsion is cooled to room temperature and diluted with 20 ml of water. The two phases are separated, and the organic phase is dried over MgSO4 and evaporated in vacuo. The liquid crude product is purified by medium-pressure chromatography. 3.1 g of N-butyl-N-acetyl-2,4-difluoroaniline are obtained as a brownish oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05026625 |
| 出典データセット | uspto-grants-1991_06 |
| ORD ID | ord-97ddca6efec049b8af0e4bcb966496bc |
| 出典メモ | uspto-grants-1991_06 |