Diethyl Ether → HCID 178474468、化合物

HRID 1494611ノート

反応式

HRID 1494611 の反応式
[NH2:1][C:2]1[N:3]=[C:4]([OH:23])[C:5]2[CH:11]=[C:10]([CH:12]=[CH:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]([OH:22])=[O:21])=[CH:16][CH:15]=3)[CH:9]=[N:8][C:6]=2[N:7]=1.CC[O:26][CH2:27][CH3:28].[C:29](OC(=O)C)(=[O:31])[CH3:30]>CN(C)C1C=CN=CC=1>[C:29]([NH:1][C:2]1[N:3]=[C:4]([OH:23])[C:5]2[CH:11]=[C:10]([CH:12]=[CH:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]([O:22][C:27](=[O:26])[CH3:28])=[O:21])=[CH:16][CH:15]=3)[CH:9]=[N:8][C:6]=2[N:7]=1)(=[O:31])[CH3:30]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 178508854HCID 178508854、化合物

生成物 1

HCID 178474468HCID 178474468、化合物収率 84%

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

反応条件

温度
120 °C

実験手順

A suspension of 0.88 g of 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)ethenyl]pyrido[2,3-d]pyrimidine in 20 mL of acetic anhydride containing 0.05 g of 4-dimethylaminopyridine was heated under nitrogen at 120° C. for 3 hours. The reaction mixture was cooled to room temperature. Fifty milliliters of ether were added and the resulting yellow solid was collected by filtration to yield 0.95 g (84%) of the title compound; mp>300° C.; IR (Nujol) 3350, 3150, 1800, 1670, 1600 cm-1.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe resulting yellow solid was collected by filtration

出典と根拠

ORDレコード
ord-9feb364ee5ff42e696ca98f022a65284
出典データセット
uspto-grants-1991_06
特許番号
US05026851

反応ノート

読み込み中…