Hydrochloric Acid → 7-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

HRID 1494822ノート

反応式

HRID 1494822 の反応式
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([CH2:27][NH:28]C(=O)C)[CH:24]=4)[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([CH:32]2[CH2:34][CH2:33]2)[CH:7]=1)=[O:5])C.[ClH:35]>C(O)C>[ClH:35].[NH2:28][CH2:27][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[CH2:19][N:18]([C:11]1[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[CH:32]3[CH2:34][CH2:33]3)=[CH:13][C:12]=1[F:17])[CH2:26]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 572711897-(5-Acetamidomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester

生成物 1

HCID 679223597-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

80 mg of 7-(5-acetamidomethyl-2-isoindolinyl)-1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester was dissolved in a mixture of 10 ml of 10% hydrochloric acid and 10 ml of ethanol. The mixture was heated under reflux for 24 hours. The precipitates deposited were collected by filtration and washed with water and ethanol in this order to obtain 68 mg of 7-(5-aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. filtrationThe precipitates deposited were collected by filtration
  4. washwashed with water and ethanol in this order

出典と根拠

ORDレコード
ord-2ec7002a7a8d43619d56c391fd13a0db
出典データセット
uspto-grants-1991_06
特許番号
US05026856

反応ノート

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