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2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 反応物 | 5-Formyl-2-methoxyphenylboronic acid | HCID 2734367 | — |
| 生成物 | 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde | HCID 24901876 | 70% |
反応手順
2,4 dichloropyrimidine and 5-formyl-2-methoxyphenylboronic acid was coupled following procedure A. The yield was 70%. LC-MS showed the product was >95% pure and had the expected M+H+ of 249. 1H NMR (Varian 300 MHz, MeOD-d6, shifts relative to the solvent peak at 3.33 ppm) δ 9.9 (s, 1H) 8.7 (d, 1H) 8.4 (s, 1H) 8.0 (d, 2H) 7.4 (d, 1H) 3.9 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-4ce789c572b7461498d343a62c43931b |
| 出典メモ | uspto-grants-2010_06 |